Endocrine Abstracts

Introduction: Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection. In sepsis, a phenomenon called obesity paradox has been described, which involves a reduction in mortality in patients with a body mass index allowing for the diagnosis of overweight and obesity. In the clinical context, the phenomenon is confirmed by current meta-analyses. The aim of the study is a systematic review and meta-analysis of studies on obesi...

Introdutcion: In recent years, thyroid microcarcinoma (TMC) predominates in the context of diagnosis and treatment of thyroid cancer. TMC has an excellent prognosis, its management is changed in the last few years, reducing surgical procedure and role of radioiodine ablation (RAI). Therefore, the question is what tests have a diagnostic value in patients with thyroid microcarcinoma after thyroidectomyThe aim of this study was to evaluate the role of 131 ...

The accumulated data underline the role of betatrophin in glucose homeostasis. Polycystic ovary syndrome (PCOS) is characterized by insulin resistance and high risk of developing prediabetes and diabetes. The aim of our study was to investigate the relationship of serum betatrophin concentrations with indirect indices of insulin resistance and insulin secretion in women with PCOS, comparing to the control group. The study group comprised 43 women with PCOS and 16 controls matc...

The aim of the study was to evaluate hormonal profile in diabetic adolescent girls with menstrual disorders and compare them to regularly menstruating diabetic and healthy girls.We studied 54 adolescent girls with T1DM treated with intensive and continuous insulin therapy in the chronological age of 15.9±1.3 years and gynecological age of 33.7±16.7 months with the mean HbA1c for the last year 7.4±1.5%. In 18 (33%) girls menstrual disturban...

Introduction: The length of patient survival after cancer treatment is increasing and, in some cases, does not differ from the average life span in healthy individuals. The aim of the study is to evaluate thyroid function after oncologic treatment in children.Description of Methods: A group of 158 patients aged 16–25 who underwent oncologic treatment in childhood and the control group – 66 children and young adults were examined. The prospectiv...

Objective: It has been shown that women with PCOS as well as with autoimmune thyroiditis (AIT), are characterized by increased incidence of infertility. Serum anti-Müllerian hormone (AMH), which reflects ovarian reserve, is elevated in PCOS women and is decreased in women with AIT. The Rotterdam criteria recognize four clinical PCOS phenotypes,i.e.,phenotype Acharacterized by clinical and/or biochemical hyperandrogenism (HA), menstrual dysfunction (oligo/amenorrhea) (Olig...

Introduction: Very late step growth is quite rare, and probably very rare, if there is, 10 years after the end of treatment with GH. Therefore, we would like to present our patient, even though we cannot yet give a full pathomechanism of his disorders.Case report: A man 28 years, was admitted to us to assess hormonal status before elective hip surgery. He had congenital brain toxoplasmosis. From 8 to 16 years he was treated with GH without a good effect....

Introduction: Adiponectin is an adipocytokine with insulin-sensitizing and anti-inflammatory properties. In skeletal muscle, it increases fatty acid oxidation and insulin-stimulated glucose uptake through binding with adiponectin receptor 1 (AdipoR1). The aim of our study was to assess the effect of insulin and Intralipid/heparin infusions on muscle AdipoR1 expression in humans.Methods: Twenty healthy male subjects (age 25.2±3.2 years; BMI, 26.5&#17...

Introduction: Glycoprotein 130 (gp130) cytokines, like interleukin 6 (IL6), act through plasma membrane receptors consisting of two glycoproteins: a cytokine binding subunit (like IL6R) and gp130, responsible for signal transduction. IL6 may regulate insulin sensitivity in a dual manner, as both insulin-sensitizing and -desensitizing actions have been reported. Other gp130 cytokines may have a beneficial metabolic effects. The aim of the present study was to assess skeletal mu...

Introduction: Numerous studies indicate an association between low-grade chronic inflammation and predisposition to type 2 diabetes and atherosclerosis. IL18 is a proinflammatory cytokine with proatherogenic properties. Existing evidence indicated that circulating IL18 was associated with insulin resistance, metabolic syndrome and type 2 diabetes. Some data suggest that endogenous IL18 signaling modulates food intake, metabolism and adiposity, as homeostatic regulator. The aim...